Ib tug txiv neej 53-xyoo-laus tus neeg mob, nrog keeb kwm yav dhau los cim los ntawm kev ua kom tiav gastrectomy, xav tias tau txhawb nqa Wernicke's encephalopathy. Tus kws kho mob tshwj xeeb tau pom zoo rau cov tshuaj txhaj tshuaj (IV) sib xyaw ntawm 100 mg vitamin B1 infusion hauv 100 mL ntawm cov ntsev zoo tib yam, kom tswj tau txhua 8 teev. Txawm li cas los xij, lub chaw IV compounding tau tsis kam npaj cov tshuaj, raws li cov lus qhia cov khoom qhia meej meej tias Vitamin B1 Thiamine HCl hmoovKev txhaj tshuaj yuav tsum tau txhaj tshuaj intramuscular (IM).
Vim li cas thiaj tsis tuaj yeem txhaj tshuaj vitamin B1 hauv cov hlab ntsha?
Vitamin B1 yog handily decomposed thiab annihilated nyob rau hauv alkaline daws, tshwj xeeb tshaj yog thaum sov. Nws tuaj yeem ua rau tsis zoo thaum koom nrog cov tshuaj alkaline (xws li sodium phenobarbital, sodium bicarbonate, thiab potassium citrate). Vitamin B1 ruaj khov dua hauv cov kua qaub, thiab tuaj yeem tiv taus 100 degree sterilization ntawm pH ntawm 3.5, tab sis maj mam poob nws cov txiaj ntsig ntawm pH qhov tseem ceeb tshaj 5.
Kev tshuaj xyuas cov lus qhia ntawm ntau lub tuam txhab tsim khoom hauv tsev, txoj hauv kev ntawm kev tswj hwm tsuas yog hais txog kev txhaj tshuaj IM. Cov tshuaj tiv thaiv tsis zoo sau tseg tias nrog kev txhaj tshuaj IM siab, yuav tsum tau them nyiaj rau qhov kev pheej hmoo ntawm kev tsis haum tshuaj, xws li nqos nyuaj, khaus tawv nqaij, lub ntsej muag / di ncauj / lub qhov muag edema, thiab hawb pob. Cov kev ceev faj tseem hais txog qhov muaj peev xwm ntawm kev tsis haum tshuaj thaum txhaj tshuaj, thiab ceeb toom rau cov neeg uas muaj kev tsis haum tshuaj.
Phau ntawv "Tshiab Pharmacology" tsuas yog hais txog kev txhaj tshuaj IM thiab tawm tswv yim tawm tsam IV kev tswj hwm. Ib yam li ntawd, "Clinical Drug Use Guide for Chinese Physicians and Pharmacists" tsuas yog pom zoo IM txhaj tshuaj rau beriberi hnyav, nrog rau kev hloov mus rau kev tswj qhov ncauj tom qab cov tsos mob txhim kho.
Kev ruaj ntseg:
Raws li cov khoom siv tshuaj lom neeg ntawm thiamine hydrochloride, cov tuam txhab tsim khoom yuav tsum tswj cov pH ntawm cov khoom nruab nrab rau kev txhaj tshuaj vitamin B1 ntawm 2.5-4.0, thiab tom qab ntawd ua 100 degree sterilization . Xyoo 2015 version ntawm Suav Pharmacopeia kuj qhia tau tias pH ntawm vitamin B1 infusion yuav tsum nyob nruab nrab ntawm 2.5-4.0. Cov European Pharmacopoeia 6.8 thiab US Pharmacopeia 33 kuj muaj cov pH zoo sib xws rau cov tshuaj thiamine hydrochloride.
Yog li ntawd, los ntawm qhov kev xav ntawm kev ruaj ntseg, yog tias txhaj tshuaj vitamin B1 tau muab tso rau hauv cov hlab ntsha, kev hloov pauv hauv cov kuab pH yuav ua rau cov thiamine hydrochloride decomposition.
Kev nyab xeeb:
Ob qho tib si cov lus qhia thiab cov ntaub ntawv tseem ceeb hais tias kev txhaj tshuaj vitamin B1 tuaj yeem ua rau muaj kev tsis haum tshuaj, thiab qee zaum, txawm tias anaphylactic shock. Txawm hais tias qhov tshwm sim ntawm kev tsis haum tshuaj nrog kev txhaj tshuaj ntawm cov tshuaj vitamin B1 tsis meej, kev tshawb fawb ntawm PubMed qhia ob peb kis.
Martindale Drug Reference hais txog qhov ntawdVitamin B1 Thiamine HCl hmoovtuaj yeem ua rau hypersensitivity tshwm sim, feem ntau tshwm sim tom qab kev tswj hwm parenteral. Nyob nruab nrab ntawm xyoo 1970 thiab Lub Xya Hli 1988, UK CSM tau txais 90 cov lus ceeb toom ntawm qhov tsis zoo tom qab txhaj tshuaj B-complex vitamins thiab vitamin C, feem ntau yog kev tsis haum tshuaj (41 tus neeg, suav nrog 2 tus neeg tuag), ua pa nyuaj lossis bronchospasm (13). mob), thiab pob khaus thiab dej (22 kis). 78 ntawm cov kev tshwm sim no tshwm sim thaum lossis tam sim tom qab txhaj tshuaj IV, thaum lwm qhov 12 tshwm sim tom qab txhaj tshuaj IM.
Lawv pom zoo tias kev kho parenteral yuav tsum tsuas yog siv thaum tsim nyog kiag li, thiab nyob rau hauv lub xub ntiag ntawm cov khoom siv los kho cov kev tsis haum tshuaj. Juel J. et al. ntseeg hais tias kev txhaj tshuaj vitamin B1 muaj kev nyab xeeb siab, tab sis tseem tuaj yeem ua rau muaj kev tsis haum tshuaj lossis kev tsis haum tshuaj, uas feem ntau tshwm sim nrog kev tswj hwm IV.
Yog li, kev txhaj tshuaj IM yuav muaj kev nyab xeeb dua li kev txhaj tshuaj IV, tab sis kev soj ntsuam ntawm Wrenn KD. ua al. qhia tias rau cov neeg mob tsis noj zaub mov, IV kev tswj hwm ntawm vitamin B1 zoo li muaj kev nyab xeeb zoo li IM txhaj tshuaj.
Raws li ib qho ntawm cov kws tshaj lij tshaj plawsVitamin B1 Thiamine HCl hmoovtuam ntxhab thiab cov muag khoom nyob rau hauv Suav teb, Qyherb yog tshwj xeeb hauv cov kev pabcuam zoo thiab cov nqi sib tw. Yog tias koj xav tau kev lag luam wholesale, thov hu rau peb ntawm info@dnbiology.com.