Nyob rau hauv lub ntiaj teb niaj hnub no, vim muaj kev monopoly thiab tsis muaj kev kho mob siab heev, cov nroj tsuag nrog cov khoom siv tshuaj tau dhau los ua cov peev txheej kho mob tseem ceeb hauv cov tebchaws tsim. Daim teb no hu ua tshuaj tsoos tshuaj, tshuaj hauv paus txawm los yog tshuaj pej xeem. Raws li WHO lub ntsiab lus, cov thev naus laus zis no yog ua raws li kev xav ntawm ntau yam kev kho mob, xws li kev paub txog kev paub, kev txawj thiab kev coj ua, thiab feem ntau siv tau rau kev tiv thaiv, kuaj mob, txhim kho lossis kho ntau yam kab mob. Ntawm lawv, ceg ntawm "kev tshawb fawb ntawm kev sib cuam tshuam ntawm tib neeg thiab cov nroj tsuag" tau txais kev mloog ntau thiab ntau dua. Raws li kev tshawb fawb tob ntawm ethnobotany, ntau lub tebchaw ntuj muaj cov haujlwm zoo tshuaj, xws li kev ua haujlwm antioxidant, kev ua haujlwm tiv thaiv kab mob thiab tiv thaiv kev ua haujlwm. Kev ua kis kab mob, thiab lwm yam, yog li lawv tuaj yeem tsim los rau qee yam hauv cov tshuaj tiv thaiv kab mob, tshuaj tua kab mob, tshuaj tiv thaiv spasmodics, tshuaj tiv thaiv ntshav qab zib, tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob.
Lub ntsiab tseem ceeb ntawm iab saj hauv coptis yog berberine, uas yog berberine hydrochloride. Qhov no yog ib qho isoquinoline alkaloid faib rau hauv ntau yam tshuaj ntsuab. Nws muaj nyob rau hauv Coptis chinensis nyob rau hauv daim ntawv ntawm hydrochloride (berberine hydrochloride). Kev tshawb fawb tau pom tias cov tshuaj no tuaj yeem siv los kho cov qog, kab mob siab, thiab kab mob plawv. , kub siab, mob, kab mob thiab kab mob, raws plab, kho cov kab mob xws li Alzheimer's kab mob thiab mob caj dab.
Keeb kwm ntawm Berberine Hydrochloride Powder
Berberine Hydrochloride hmoovtau pom thawj zaug hauv lub sijhawm ua ntej Qin. Nrog rau kev nkag siab ntxiv ntawm kev tshawb fawb tshuaj, qhov ua tau zoo ntawm coptis tau sau tseg hauv kev nthuav dav hauv "Shen Nong's Materia Medica" ntawm Han Dynasty hauv Suav teb. Phau ntawv no yog phau ntawv tshuaj suav tshuaj suav ntxov tshaj plaws. Nws yog hais tias nws yog los ntawm Shennong tsev neeg. , muab sau ua ib phau ntawv ntawm 25 thiab 220 AD thaum lub sij hawm Eastern Han Dynasty. Nws cov qauv siv lead ua ib zaug tau txheeb xyuas thawj zaug los ntawm kev rho tawm los ntawm Hydrastiscanadensis hauv xyoo 1917.
Lub Hom Phiaj Tshuaj ntawm berberine hcl hmoov
1. Antioxidant nyhuv
Raws li ib txwm muaj, lub cev tswj hwm qhov sib npaug ntawm cov tshuaj antioxidants thiab pro-oxidants. Oxidative stress yog cov txheej txheem tsim kev puas tsuaj uas tej zaum yuav yog ib qho tseem ceeb ntawm kev sib haum xeeb ntawm kev puas tsuaj rau cov txheej txheem ntawm tes, yog li ua rau muaj ntau yam kab mob xws li kab mob plawv, mob qog noj ntshav, kab mob neurological, thiab ntshav qab zib. Kev tsim tawm ntau dhau ntawm cov pa oxygen reactive (ROS), feem ntau dhau los ntawm overstimulation ntawm NADPH los ntawm cytokines lossis los ntawm mitochondrial electron thauj saw thiab xanthine oxidase, tuaj yeem ua rau oxidative kev nyuaj siab. Kev sim tau pom tias berberine metabolites thiab berberine qhia tau zoo heev -OH scavenging kev ua si, thiab lawv cov teebmeem yog roughly sib npaug rau cov haib antioxidant vitamin C. Qhov nce hauv SOD (superoxide dismutase) kev ua thiab txo qis hauv MDA (ib qho cim ntawm lipid peroxidation) qib. tuaj yeem saib xyuas los ntawm kev tswj hwm berberine rau cov kab mob ntshav qab zib hom nas [1]. Cov txiaj ntsig ntxiv tau pom tias qhov kev ua si ntawm berberine muaj feem cuam tshuam nrog nws txoj haujlwm ferrous ion chelating, thiab C-9 hydroxyl pawg ntawm berberine yog ib qho tseem ceeb.
2. Antitumor nyhuv
Muaj ntau cov lus ceeb toom txog kev tiv thaiv mob qog noj ntshav ntawm berberine. Ntau yam kev tshawb fawb nyob rau xyoo tas los no tau pom tias berberine muaj txiaj ntsig zoo hauv kev kho mob qog noj ntshav ntawm zes qe menyuam, mob qog noj ntshav endometrial, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob ntsws cancer, mob qog noj ntshav, mob qog nqaij hlav hauv lub raum, nws yog qhov tseem ceeb hauv kev kho mob qog noj ntshav loj xws li. raws li mob qog noj ntshav thiab qog nqaij hlav prostate. Berberine tuaj yeem cuam tshuam kev loj hlob ntawm cov qog hlwb los ntawm kev cuam tshuam nrog ntau lub hom phiaj thiab cov txheej txheem. Nws tuaj yeem hloov qhov kev qhia ntawm oncogenes thiab carcinogenesis ntsig txog cov noob los tswj cov haujlwm ntawm cov enzymes cuam tshuam thiab inhibit kev loj hlob.
3. Kab mob plawv
Berberine hcl hmoov plays lub luag haujlwm tseem ceeb hauv kev kho cov kab mob plawv thiab muaj ntau yam kev siv. Berberine ua tiav lub hom phiaj ntawm kev tiv thaiv arrhythmia los ntawm kev txo qhov tshwm sim ntawm kev ua haujlwm ntxov ntxov ntawm lub ventricular contractions thiab inhibiting qhov tshwm sim ntawm ventricular tachycardia. Qhov thib ob, dyslipidemia yog qhov tseem ceeb tshaj plaws rau cov kab mob plawv thiab yog tus cwj pwm los ntawm kev nce qib ntawm tag nrho cov roj (cholesterol), triglycerides, thiab qis lipoprotein cholesterol (LDL), thiab txo qis ntawm high-density lipoprotein (HDL), whereas berberine kev ruaj ntseg ntawm cov ntsuas no tuaj yeem tswj tau zoo heev. Lub sijhawm ntev hyperlipidemia yog ib qho tseem ceeb ntawm kev tsim cov atherosclerotic plaque. Nws tau raug tshaj tawm tias berberine cuam tshuam rau LDL receptors hauv daim siab hlwb kom txo qis tib neeg cov roj cholesterol hauv cov hepatocytes. Tsis tas li ntawd xwb, berberine muaj cov txiaj ntsig zoo inotropic thiab tau siv los kho lub plawv tsis ua haujlwm.
Kev txhim kho yav tom ntej ntawm Berberine Hydrochloride Powder
Txawm hais tias berberine hcl hmoov tau siv dav hauv kev kho mob, ib qho tsis zoo uas tsis tuaj yeem tsis quav ntsej yog tias nws yog cov tshuaj BCS class II thiab muaj cov dej tsis zoo, uas tsis zoo rau cov neeg mob nqus. Yog li ntawd, yuav ua li cas los tsim cov tshuaj tsim nyog tam sim no yog ib qho teeb meem. Teeb meem yuav daws tau.
Cov tshuaj feem ntau siv nyob rau hauv lub tsev muag tshuaj kom nce dej solubility feem ntau yog ntxiv cov dej-soluble excipients ntau, tab sis cov teeb meem uas tuaj nrog nws yog txo kom tsawg npaum li cas thiab cov neeg mob ua raws. Yog li ntawd, yuav tsum muaj ib txoj hauv kev tsim nyog ntxiv rau cov tshuaj bioavailability. qib kev txhim kho. Feem ntau siv txoj kev muaj xws li amorphous dispersions, tshuaj ntsev thiab tshuaj co-crystals, tab sis amorphous feem ntau tseem yuav tsum tau excipients los tswj lawv cov stability, thaum lub applicability ntawm ntsev yog feem ntau siv rau cov tshuaj nrog ionizable pawg. Nyob rau hauv sib piv, cov tshuaj eutectic qhia tau hais tias nws superiority: cov txheej txheem yooj yim, tsis tshua muaj nqi, thiab zoo heev nyhuv.
Muaj ob lub ntsiab ntawm cov tshuaj uas twb muaj lawm co-crystal tsim rau berberine hydrochloride. Ib qho yog tsim kom muaj cov xim co-crystal nrog cov kua qaub ligands, thiab lwm qhov yog los ua ib co-crystal nrog flavonoids. Cov qub muaj kev txhim kho ntau dua hauv bioavailability, tab sis seb cov ligand puas tuaj yeem siv rau kev kho mob mus sij hawm ntev tseem yuav raug txheeb xyuas. Thaum lub co-crystal tsim nrog flavonoids tsis muaj kev txhim kho bioavailability zoo li yav dhau los, nws yog cleverly tsim los ntawm siv lead ua engineering. Txoj kev txhim kho kev sib xyaw ua ke ntawm ob qho tshuaj me me, uas tuaj yeem ua ke txhim kho kev ua tau zoo ntawm ob qho tib si. Nws yog ib txoj kev ua tau zoo ntawm kev txhim kho lub cev thiab tshuaj lom neeg.
Daim duab qhov chaw: 《Ob Cocrystals ntawm Berberine Chloride nrog Myricetin thiab Dihydromyricetin: Crystal Structures, Characterization, thiab Antitumor Activities express, doi: 10.1021/acs.cgd.9b00939)
Niaj hnub no,Berberine Hydrochloride hmoovtuaj yeem tsim cov khoom tsim thiab hloov kho los ntawm cov txheej txheem siv lead ua engineering nrog tus nqi qis thiab cov thev naus laus zis siab heev. Nrog rau kev txhim kho ntawm kev tshawb fawb kev kho mob thiab kev sib sib zog nqus ntawm kev tshawb fawb tshuaj, berberine hydrochloride yuav muaj tseeb qhia ntau yam tshuaj. Siv cov teebmeem. Ntawm qhov tod tes, berberine hydrochloride tsis tau tsuas yog ua tiav cov txiaj ntsig zoo kawg nkaus hauv kev tshawb fawb tshuaj tshuaj ntawm tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tiv thaiv kab mob, tiv thaiv qog, tiv thaiv kab mob ntshav qab zib, thiab kho cov kab mob plawv thiab cerebrovascular, tab sis nws siv lead ua engineering tsim thiab morphological tsom xam. kuj muaj kev txhawj xeeb thoob plaws. Vim nws cov nyhuv curative zoo kawg thiab tsis tshua muaj tshwm sim, nws muaj peev xwm loj hauv kev kho mob daim ntawv thov thiab muaj kev cia siab dav. Nrog rau txoj kev loj hlob ntawm cell biology, lub pharmacological mechanism ntawm berberine yuav elucidated los ntawm cov cellular theem mus rau qib molecular thiab lub hom phiaj, muab ntau theoretical hauv paus rau nws cov kev kho mob daim ntawv thov.