Raws li caffeic acid derivative,Echinacea extractcichoric acid muaj qhov tseem ceeb los tiv thaiv -inflammatory thiab antioxidant teebmeem. Nws tuaj yeem siv los kho cov kab mob neuroinflamation los ntawm cov kab mob hauv lub cev, tiv thaiv -atherosclerosis, hypoglycemic. Kab lus no piav qhia txog cov txheej txheem ntawm kev ua antioxidant ntawm Echinacea Purpurea cichoric acid.
1. Txo MDA thiab ROS qib
Cov kev tshawb fawb tau pom tias cichoric acid tuaj yeem txo qis MDA thiab ROS. Chichoric acid tuaj yeem ua rau muaj kev ua haujlwm ntawm GSH-Px thiab SOD thaum txo cov ntsiab lus ntawm MDA. SOD yog lub ntsiab enzyme kom tshem tawm cov pa dawb radicals hauv lub cev. Yog li, cichoric acid tuaj yeem txo qhov kev puas tsuaj los ntawm lipid peroxidation hauv lub cev, txhim kho lub peev xwm antioxidant ntawm lub cev, thiab tswj kom muaj qhov sib npaug ntawm redox hauv lub cev.
2. Ua kom txoj hauv kev Nrf2
Cichoric acid tuaj yeem ua rau ntawm Nrf2/Keap1 signaling pathway, los ntawm kev txhim kho cell viability thiab txhim kho mitochondrial muaj nuj nqi. Li no nce qib kev nthuav qhia ntawm cov proteins uas muaj feem xyuam thiab qis qis antioxidant tiv thaiv enzymes HO-1 thiab NQO1. Qhov no qhia tau tias cichoric acid tuaj yeem tswj tau qhov sib npaug redox hauv hlwb. Lub caij no, cichoric acid tuaj yeem tiv thaiv daim siab hlwb los ntawm kev puas tsuaj oxidative los ntawm kev ua kom Nrf2 txoj hauv kev.
Cov methylated metabolites ntawm cichoric acid kuj muaj antioxidant zog. Nws tiv thaiv oxidative kev nyuaj siab los ntawm kev cuam tshuam rau Keap1 / Nrf2 txoj hauv kev thiab txo qis kev ua haujlwm enzyme.
3. Ua kom txoj hauv kev AMPK
AMPK yog ib qho tseem ceeb ntawm cellular zog sensor uas ua lub luag haujlwm tseem ceeb hauv kev tswj lub zog metabolism, tiv thaiv - mob, thiab tiv thaiv - oxidation. Activated AMPK tuaj yeem tsis tsuas yog thaiv qee txoj hauv kev taw qhia thiab txo qhov kev qhia ntawm pro- cov kab mob inflammatory, tab sis tseem thaiv cov lus teb oxidative kev nyuaj siab.
Echinacea extracttuaj yeem txhim kho cov dej num ntawm glutathione peroxidase (GPx) thiab superoxide dismutase (SOD) los ntawm kev ua kom txoj hauv kev AMPK. Thaum kawg, nws muaj cov nyhuv antioxidant.