Cov neeg laus laus tau dhau los ua qhov tseem ceeb ntawm cov qauv kev noj qab haus huv niaj hnub no, thiab kev tiv thaiv kev laus yog ib qho tseem ceeb ntawm kev tshawb fawb txog kev kho mob tam sim no.Icariin, monomer tivthaiv ntawm tsoos suav tshuaj Epimedium, muaj kev tiv thaiv kev laus txog kev ua haujlwm.
Yuav Ua Li Cas Icariin Anti-aging?
1. Txhim kho cell secretory phenotype
Ib qho tseem ceeb molecular feature txuam nrog kev laus yog telomere shortening. Shortened telomeres ua rau cov qauv tsis ruaj khov ntawm cov cell chromosomes.
Epimedium tag nrho cov flavonoids tuaj yeem ua rau kom ntev ntawm telomere hauv cov hlwb senescent thiab ua kom ntev lub neej ntawm tib neeg diploid fibroblasts. Cov txheej txheem yuav ua rau inhibit qhov kev qhia ntawm p16 noob, yog li ua kom cov haujlwm ntawm phosphorylated cellular retinoblastoma protein.
Hauv kev xaus, icariin muaj kev tiv thaiv kev tiv thaiv ntawm cell senescence induced nyob rau hauv txawv ib puag ncig. Los ntawm kev txhim kho lub cell secretory phenotype, txhawb nqa cell proliferation, thiab reactivating nws txoj kev loj hlob voj voog, nws ua tiav qhov kev cia siab ntawm kev cuam tshuam hauv cell aging txheej txheem.
2. Inhibit oxidative kev nyuaj siab
Qhov tsis sib xws ntawm oxidation thiab antioxidants hauv lub cev tuaj yeem ua rau oxidative puas hauv lub cev, lub xeev hu ua oxidative stress (OS). Mitochondria tsim cov pa oxygen ntau dhau (ROS), ua rau lipid peroxidation thiab telomeric DNA strand puas. Cov kab mob metabolic tsis zoo ua rau apoptosis thiab ua rau cov ntaub so ntswg thiab cov kabmob, uas yog ib qho laj thawj tseem ceeb rau kev laus ntawm lub cev.
Icariin muaj zog antioxidant zog. Nws tuaj yeem tshem tawm cov dawb radicals los ntawm inhibiting ntau oxidation, kho mitochondrial DNA puas, hloov lub puab mitochondrial membrane thiab molecular ATP, thiab tswj kev ruaj ntseg ntawm genome.
3. Txhim kho kev tiv thaiv
Kev laus ntawm lub cev yog nrog los ntawm kev poob qis hauv kev tiv thaiv kab mob, uas cuam tshuam nrog kev laus ntawm lub cev tiv thaiv kab mob, suav nrog kev txo qis hauv cov lej thiab kev ua haujlwm ntawm T hlwb thiab B hlwb. Thiab qhov kev hloov pauv hauv qhov kev qhia profile ntawm molecules ntawm qhov chaw ntawm lub ntuj killer hlwb.
Icariin muaj ob txoj kev immunomodulatory nyhuv, txhawb kev sib txawv ntawm lub cev tiv thaiv kab mob, thiab tib lub sij hawm muaj cov nyhuv anti-inflammatory.